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SGLT2i临床应用 | 学习笔记

  • 2026-02-25 10:36:04
SGLT2i临床应用 | 学习笔记

SGLT2i临床应用 | 学习笔记

💡 核心定义/机制
SGLT2i通过抑制肾脏近端小管葡萄糖重吸收实现降糖，仅限成人T2DM使用，单药治疗安全性高，但联合用药需严密调整剂量。

📋 适应证与禁忌分级
• 适用人群：可单用或联合其他药物治疗成人T2DM
• 禁忌人群：在 1型糖尿病（T1DM） 、青少年及儿童中无适应证
• 低血糖风险：单药治疗不增加低血糖风险，与胰岛素或胰岛素促泌剂联用时应下调剂量

✓ 临床用药实施路径
确认成人T2DM诊断 → 评估单药或联合需求 → 避免用于T1DM及未成年人 → 如联用胰岛素/促泌剂 → 下调胰岛素或促泌剂剂量 → 监测血糖及不良反应
核心原则：严格把握适应证，联合用药主动防低糖

⚠️ 关键用药警示
【适应证红线】 ：T1DM、青少年及儿童禁用，目前无获批适应证
【低血糖防控】 ：单药虽安全，但与胰岛素或胰岛素促泌剂联用必须下调剂量
【人群限定】 ：仅限成人T2DM患者，不可超范围使用

📌 Tags
#内分泌代谢 #糖尿病 #SGLT2i #T2DM #用药安全 #低血糖风险 #临床指南 #药物相互作用 #医学生

👉 获取【PPT】请参考以下链接：
中国糖尿病防治指南(2024 版)-第九章-1|学习笔记PPT

作者提示: 健康医疗分享，仅供参考
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  1. CONNECT:[ UseTime:0.000620s ] mysql:host=127.0.0.1;port=3306;dbname=no_67808;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000815s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000294s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000274s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000568s ]
  6. SELECT * FROM `set` [ RunTime:0.000211s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000630s ]
  8. SELECT * FROM `article` WHERE `id` = 470277 LIMIT 1 [ RunTime:0.000383s ]
  9. UPDATE `article` SET `lasttime` = 1772000643 WHERE `id` = 470277 [ RunTime:0.014459s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000358s ]
  11. SELECT * FROM `article` WHERE `id` < 470277 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.005940s ]
  12. SELECT * FROM `article` WHERE `id` > 470277 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000526s ]
  13. SELECT * FROM `article` WHERE `id` < 470277 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000703s ]
  14. SELECT * FROM `article` WHERE `id` < 470277 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001262s ]
  15. SELECT * FROM `article` WHERE `id` < 470277 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.009421s ]
0.104284s