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甲状腺学习笔记之4:液基中PTC特异性新指标——核仁周空晕

  • 2026-03-25 00:39:55
甲状腺学习笔记之4:液基中PTC特异性新指标——核仁周空晕
      上图 甲状腺乳头状癌中可见扭曲的细胞核。超过一半的核膜呈现锯齿状不规则。核仁嗜酸性，并伴有核仁周围空晕，如红色箭头。（巴氏染色，液基标本，X1000）
日本学者Suzuki等[1]观察了甲状腺乳头状癌在液基细胞学标本（LBC）与传统涂片中的差异，发现了一个在SurePath液基细胞学标本中对甲状腺乳头状癌的具有特异性的新形态学指标------核仁周空晕（Perinucleolar halo），参见上图：

      1.形态描述：细胞核仁周围出现一圈清晰的空晕区域。

      2.特异性：在研究中，特异性高达96.1%。

    3.重要性：是LBC中另一个高特异性的指标，与PTC卷曲核结合，可提高诊断信心。

参考文献
[1]Suzuki A, Hirokawa M, Higuchi M, etal. Cytological characteristics of papillary thyroid carcinoma on LBC specimens, compared with conventional specimens. Diagn Cytopathol. 2015,43(2):108-113. 
【相关链接】
甲状腺学习笔记之1：乳头状癌的核特征
甲状腺学习笔记之2：NIFTP的注释
甲状腺学习笔记之3：PTC在液基与传统涂片中的差异
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  12. SELECT * FROM `article` WHERE `id` > 477313 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.004356s ]
  13. SELECT * FROM `article` WHERE `id` < 477313 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.001310s ]
  14. SELECT * FROM `article` WHERE `id` < 477313 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001966s ]
  15. SELECT * FROM `article` WHERE `id` < 477313 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.001438s ]
0.115863s