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病理学习笔记-知识点!知识点!

  • 2026-03-06 02:45:00
病理学习笔记-知识点!知识点!
宫颈浸润性鳞状细胞癌有几种亚型？
答案：9种。
1.角化型鳞状细胞癌：需出现角化珠。
2.非角化型鳞状细胞癌：最多见，具有鳞状上皮特征，但无角化珠。
3.基底细胞样鳞状细胞癌：小的，形似高级别累腺的基底样细胞组成。
4.疣状癌：高分化，好发于老年女性；细胞分化好，角化层厚，似良性；粗大乳头+缺乏纤维血管轴心及挖空细胞+推挤式浸润（无孤立癌巢）。
5.湿疣状癌：形似湿疣或外阴的鲍样丘疹病；乳头结构+挖空细胞+浸润性病灶（可有角化）；P16常阳性，但P53野生型。
6.乳头状鳞状细胞癌：大的外生性肿物+粗大/纤细乳头+纤维血管轴心+似HISL异型细胞+无挖空细胞+间质浸润/无浸润。
7.淋巴上皮瘤样癌：细胞大小一致，核空泡状，可见核分，胞质淡染，散在/成簇分布在丰富的淋巴组织中，与EBV感染无关。
8.肉瘤样癌：表层鳞状细胞癌+深层梭形肉瘤样细胞，都可表达P40，预后差，注意与恶性米勒管混合瘤（多见于宫体，除肉瘤外，可见分化的腺癌成分）相鉴别。
9.HPV非依赖性鳞状细胞癌：指经过高敏感的HPV检测技术未能在肿瘤中检测到HPV成分，余形态同普通鳞状细胞癌，P16非大片块状表达，部分病例可呈现P53的异常表达（全阴或过表达）。

参考资料：

1.《妇产科病理学》，第3版，郑文新等主编；

写在最后：本小白不生产知识，只搬运知识，望各位大佬多多指导，如有侵权及错误之处，及时联系。

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  1. CONNECT:[ UseTime:0.000568s ] mysql:host=127.0.0.1;port=3306;dbname=no_67808;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000923s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000449s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000273s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000508s ]
  6. SELECT * FROM `set` [ RunTime:0.000228s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000598s ]
  8. SELECT * FROM `article` WHERE `id` = 472326 LIMIT 1 [ RunTime:0.000363s ]
  9. UPDATE `article` SET `lasttime` = 1772782128 WHERE `id` = 472326 [ RunTime:0.003790s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000249s ]
  11. SELECT * FROM `article` WHERE `id` < 472326 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000438s ]
  12. SELECT * FROM `article` WHERE `id` > 472326 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000390s ]
  13. SELECT * FROM `article` WHERE `id` < 472326 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.002052s ]
  14. SELECT * FROM `article` WHERE `id` < 472326 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001658s ]
  15. SELECT * FROM `article` WHERE `id` < 472326 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.003885s ]
0.084400s