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碎片化学习笔记---01

  • 2026-03-25 00:22:06
碎片化学习笔记---01
寄蜉蝣于天地，渺沧海之一粟。
笔记来源：

我们科里病人这个值几乎都高。

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BNP解析：来源公众号“临床用药评价”、“检验星空”
B型脑钠肽(BNP)于1988年被日本学者首先在猪脑中分离出来，左心室是其主要分泌场所，在受到心肌细胞的刺激后（例如 心肌细胞拉伸），proBNP在蛋白酶作用下列解为NT-proBNP（氨基末端-proBNP或N端-proBNP）和生物活性激素BNP。
两者来源相同并且等摩尔分泌。两者主要由心室肌产生并分泌入血，因此测定血液中BNP或NT-pro BNP水平可对心衰进行诊断和危险评估。BNP的清除是通过与BNP清除受体结合、中性肽链内切酶清除，少部分通过肾脏代谢清除；而NT-pro BNP缺乏主动清除机制，主要经肾脏排泄被动清除。

BNP的分泌、释放及清除
BNP有利尿、利钠、降压的生物功能，NT-pro BNP无生物功能，且半衰期更长。
NT-pro BNP与BNP的比较
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  1. CONNECT:[ UseTime:0.000582s ] mysql:host=127.0.0.1;port=3306;dbname=no_67808;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000933s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000376s ]
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  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000503s ]
  6. SELECT * FROM `set` [ RunTime:0.000219s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000558s ]
  8. SELECT * FROM `article` WHERE `id` = 475573 LIMIT 1 [ RunTime:0.000396s ]
  9. UPDATE `article` SET `lasttime` = 1774382016 WHERE `id` = 475573 [ RunTime:0.018141s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000255s ]
  11. SELECT * FROM `article` WHERE `id` < 475573 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000428s ]
  12. SELECT * FROM `article` WHERE `id` > 475573 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000637s ]
  13. SELECT * FROM `article` WHERE `id` < 475573 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.002200s ]
  14. SELECT * FROM `article` WHERE `id` < 475573 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.002500s ]
  15. SELECT * FROM `article` WHERE `id` < 475573 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.002107s ]
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